Evidence map›Paper›PMID 42767220›Full record

ArticleCell chemical biology2026

G protein diffusion states reveal receptor binding dynamics at single-molecule scale.

Signe Mathiasen, Jozsef Meszaros, Chase Webb, Peter Geggier, Wesley B Asher, Nevin A Lambert, Jonathan A Javitch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Signe MathiasenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: signe.mathiasen@sund.ku.dk.
Jozsef MeszarosDepartments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY 10032, USA.
Chase WebbDepartments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY 10032, USA.
Peter GeggierDepartments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY 10032, USA.
Wesley B AsherDepartments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY 10032, USA.
Nevin A LambertDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Jonathan A JavitchDepartments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Division of Preclinical Research, New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address: jaj2@cumc.columbia.edu.

Funding

Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
NIMH NIH HHS R01 MH054137
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) signal through heterotrimeric G proteins, yet the kinetics of receptor-G protein interactions in cells remain poorly understood. Using single-molecule imaging, we tracked individual Gα

Indexed as

diffusiondopamine D2 receptorefficacyG protein activationHaloTaghidden Markov modellive-cell imagingsingle-molecule imagingsingle-particle trackingTIRF microscopy

Identifiers

PMID42767220
PMCPMC13669913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.