Evidence map›Paper›PMID 42767219›Full record

ArticleCurrent biology : CB2026

The teneurin TEN-1 and its ligand LRON-11 support microbiota-induced neuroprotection and mechanosensory function in C. elegans.

Jingxian Li, Juan Pablo Castillo, Shouqiang Cheng, Indya Weathers, Wioletta I Nawrocka, Jorge Alvarado, Minglei Zhao, Andrea Calixto, Engin Özkan, Demet Araç

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingxian LiDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, The University of Chicago, Chicago, IL 60637, USA.
Juan Pablo CastilloInstituto de Neurociencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.
Shouqiang ChengDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.
Indya WeathersDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, The University of Chicago, Chicago, IL 60637, USA.
Wioletta I NawrockaDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, The University of Chicago, Chicago, IL 60637, USA.
Jorge AlvaradoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.
Minglei ZhaoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Andrea CalixtoInstituto de Neurociencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile. Electronic address: andrea.calixto@uv.cl.
Engin ÖzkanDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, The University of Chicago, Chicago, IL 60637, USA. Electronic address: eozkan@uchicago.edu.
Demet AraçDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, The University of Chicago, Chicago, IL 60637, USA. Electronic address: arac@uchicago.edu.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Structural and Functional Studies of Cell-Adhesion ReceptorsR35GM148412 · NIGMS · UNIVERSITY OF CHICAGO · PI Demet Arac-Ozkan · 2023 to 2026
$2.2M
Molecular and functional characterization of repulsive guidance by Netrin complexesR01NS140594 · NINDS · UNIVERSITY OF CHICAGO · PI Engin Ozkan · 2025 to 2026
$946k
NIGMS NIH HHS R35 GM148412NIH HHS P40 OD010440NINDS NIH HHS R01 NS140594
6 · The paper itself

Abstract

Neuroprotection preserves neuronal structure and function by limiting damage and cell death, and diet-associated microbiota produce metabolites capable of influencing neuronal survival.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsMicrobiotaNeuroprotectionTenascinAnimalsLigandsNerve Tissue ProteinsCaenorhabditis elegans ProteinsLigandsNerve Tissue ProteinsTenascinteneurin-1C. eleganscryo-EM structureLRON-11LRR domainmechanosensationneuroprotectionTEN-1teneurin

Identifiers

PMID42767219
PMCPMC13633843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.