Evidence map›Paper›PMID 42767218›Full record

ArticleCurrent biology : CB2026

Heterophilic interactions between cell-surface proteins Teneurin-m and Capricious drive dendrite segregation in the Drosophila olfactory circuit.

Hui Ji, Jingxian Li, Yizhen Xu, Kenneth Kin Lam Wong, Yunming Wu, David J Luginbuhl, Yanbo Zhang, Zhuoran Li, Jaeyoon Lee, Robert C Jones and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Hui JiDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Jingxian LiDepartment of Biochemistry and Molecular Biology, the University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, the University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, the University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, the University of Chicago, Chicago, IL 60637, USA.
Yizhen XuDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Kenneth Kin Lam WongDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Yunming WuDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
David J LuginbuhlDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Yanbo ZhangDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
Zhuoran LiDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
Jaeyoon LeeDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Robert C JonesDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Stephen R QuakeDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; The Chan Zuckerberg Initiative, Redwood City, CA 94063, USA.
Demet AraçDepartment of Biochemistry and Molecular Biology, the University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, the University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, the University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, the University of Chicago, Chicago, IL 60637, USA.
Engin ÖzkanDepartment of Biochemistry and Molecular Biology, the University of Chicago, Chicago, IL 60637, USA; Neuroscience Institute, the University of Chicago, Chicago, IL 60637, USA; Institute for Biophysical Dynamics, the University of Chicago, Chicago, IL 60637, USA; Center for Mechanical Excitability, the University of Chicago, Chicago, IL 60637, USA.
Liqun LuoDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: lluo@stanford.edu.

Funding

Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
Structural and Functional Studies of Cell-Adhesion ReceptorsR35GM148412 · NIGMS · UNIVERSITY OF CHICAGO · PI Demet Arac-Ozkan · 2023 to 2026
$2.2M
Howard Hughes Medical InstituteNIDCD NIH HHS R01 DC005982NIGMS NIH HHS R35 GM148412
6 · The paper itself

Abstract

How dendrites of different neurons segregate into discrete spatial domains during neural circuit assembly is poorly understood. Here, using the Drosophila olfactory system, we found that heterophilic interactions between two cell-surface proteins, Teneurin-m (Ten-m) and Capricious (Caps), drive dendrite segregation. Ten-m and Caps are expressed in largely inverse patterns across projection neuron (PN) types when PNs are establishing their dendritic territories. Loss of Ten-m in Ten-m

Indexed as

DendritesDrosophila melanogasterDrosophila ProteinsNerve Tissue ProteinsOlfactory PathwaysAnimalsTenascinDrosophila ProteinsNerve Tissue ProteinsTenascinTen-m protein, DrosophilaAlphaFold2Capriciouscell-surface recognitioncontact-dependent repulsiondendrite segregationDrosophila melanogasterglomerular organizationneural circuit assemblyolfactory projection neuronsTeneurin-m

Identifiers

PMID42767218
PMCPMC13686033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.