Generation and epitope mapping of monoclonal antibodies targeting the avian reovirus S1133 σC protein.

Haixin Deng, Chengyu He, Kakule Mayimoto, Jiezhi Ma, Xiangdong Wu, Huansheng Wu

Abstract read

In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Haixin DengDepartment of Veterinary Preventive Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China.

Chengyu HeDepartment of Veterinary Preventive Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China.

Kakule MayimotoDepartment of Veterinary Preventive Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China.

Jiezhi MaDepartment of Veterinary Preventive Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China.

Xiangdong WuDepartment of Veterinary Preventive Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China.

Huansheng WuDepartment of Veterinary Preventive Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China. Electronic address: huanswu@jxau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Avian reovirus (ARV) causes of multisystemic, immunosuppressive infectious diseases in poultry. Among them, the σC protein, a structural component of the outer capsid encoded by the S1 genome segment, plays a crucial role in viral attachment and cellular entry. In this study, we expressed the σC protein derived from the S1133 vaccine strain was expressed in a prokaryotic system and purified it. Then, using hybridoma technology, we generated two murine monoclonal antibodies (mAbs), designated 3H and 4B and shown to specifically recognize the ARV σC protein. In order to determine the linear B-cell epitopes recognized by monoclonal antibodies 3H and 4B, we localized the epitope in the

Indexed as

Antigenic Epitope mappingAvian reovirusMonoclonal antibodyσC

Identifiers

PMID42767187

DOI10.1016/j.psj.2026.107776

PMCPMC13631903

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Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.