Evidence map›Paper›PMID 42766271›Full record

ArticleAnnals of surgical oncology2026

Ultrasound-Guided Histotripsy for Non-Invasive Treatment of Ex Vivo Soft Tissue Tumors: Preclinical Feasibility Study.

James Messina, Emma Kenna, Ryan Hubbard, Kyle Perry, Hanna Kim, Reliza Mcginnis, Gunjan Malhotra, Ashley Cornett, Jodi Wilkowski, Amanda M Shafer and 9 more

Abstract read
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In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

James MessinaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Emma KennaProgram in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.
Ryan HubbardDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Kyle PerryDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Hanna KimDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Reliza McginnisDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Gunjan MalhotraDivision of Musculoskeletal Radiology, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Ashley CornettDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Jodi WilkowskiDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Amanda M ShaferDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Wei YanDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Jonathan SukovichDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Steven B SolimanDivision of Musculoskeletal Radiology, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Geoffrey W SiegelDepartment of Orthopedic Surgery, University of Michigan, Ann Arbor, MI, USA.
Timothy HallDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
D Brock HewittDivision of Hepatobiliary and Pancreatic Surgery, NYU Grossman School of Medicine, New York, NY, USA.
Mikhail SilkDepartment of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
Zhen Xu *Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. zhenx@umich.edu.
Christina V Angeles *Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA. angelesc@med.umich.edu.ORCID http://orcid.org/0000-0002-6500-9589

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Ultrasound-guided Ultra-steerable Histotripsy Array System for Non-invasive treatment of Soft Tissue SarcomaR01EB034399 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Zhen Xu · 2023 to 2026
$2.2M
Genetically engineered mouse models to investigate the liposarcoma microenvironmentR03CA280126 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANGELES, CHRISTINA VADALA · 2024 to 2025
$156k
NIH/NCI P30CA046592NIH/NCI R03CA280126NIH NIBIB R01EB034399Rogel Cancer Center, University of Michigan Rogel Cancer Center Discovery Grant
6 · The paper itself

Abstract

backgroundSoft tissue sarcoma (STS) is a rare and heterogeneous malignancy with more than 100 histologic subtypes that can arise in virtually any part of the body. Although surgical resection is the standard of care, complete surgical resection is often limited by involvement of critical anatomy, and most subtypes are resistant to systemic therapies. Histotripsy uses microsecond length, high-pressure ultrasound (US) pulses delivered externally to generate cavitation inside the target tumor to mechanically liquefy tissue to acellular homogenate. This study tested the effect of histotripsy in a variety of soft tissue tumors (STTs) including benign tumors and sarcomas.

methodsHistotripsy was delivered to 45 surgically excised ex vivo human samples with a custom 1 MHz 8-element US transducer guided by US imaging.

resultsHistotripsy was successful in creating an identifiable treatment effect across all subtypes including adipocytic tumors, benign myxoid and nerve sheath tumors, aggressive fibrous sarcomas, and high-grade sarcomas. Immediately after histotripsy, B-mode and shear-wave elastography US imaging was shown to effectively evaluate the treatment. Tissue structure heterogeneity among the tumor subtypes dictated the variation in histologic treatment effects.

conclusionsThe data demonstrate effective US-guided histotripsy ablation on a robust cohort of ex vivo STTs. The variable treatment effects observed across tumor subtypes highlight the need for histotripsy parameter optimization, with support for its potential as a promising non-invasive treatment modality for sarcoma patients who currently have limited therapeutic options.

Indexed as

HistotripsySarcomaSoft tissue tumors

Identifiers

PMID42766271

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.