Evidence map›Paper›PMID 42766257›Full record

ArticleJournal of natural medicines2026

Ceramaximin A and B, two bromotyrosine derivatives from the worm snail Ceraesignum maximum and their cytotoxic activity.

Pham Thanh Binh, Kieu Thi Phuong Linh, Vu Thanh Trung, Pham Thi Mai Huong, Le Ba Vinh, Nguyen Phuong Thao, Nguyen Chi Mai, Tran My Linh, Nguyen Van Thanh

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Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pham Thanh BinhInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Kieu Thi Phuong LinhInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Vu Thanh TrungInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Pham Thi Mai HuongInstitute of Medicine and Pharmacy, Thanh Do University, Kim Chung, Hoai Duc, Hanoi, Vietnam.
Le Ba VinhFaculty of Science and Technology, University of Bergen, Bergen, 5007, Norway.
Nguyen Phuong ThaoInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Nguyen Chi MaiInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Tran My LinhInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Nguyen Van ThanhInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam. nvthanh1977@ich.vast.vn.ORCID http://orcid.org/0000-0002-5473-5999

Funding

Vietnam Academy of Science and Technology KHCBBI.01/23-25
6 · The paper itself

Abstract

Two previously undescribed bromotyrosine derivatives, ceramaximins A and B (1‒2), together with six known compounds (3‒8), were isolated from the worm snail Ceraesignum maximum. The structures of the new metabolites were elucidated via comprehensive spectroscopic analyses, including HRESIMS and NMR experiments, while their absolute configurations were established by comparison of experimental and TDDFT-calculated ECD spectra. A plausible biosynthetic pathway for two new compounds was proposed. Compounds 1 and 2 exhibited moderate cytotoxic activity against HepG2, HeLa, and MCF-7 human cancer cell lines, with IC

Indexed as

Bromotyrosine derivativeCeraesignum maximumMarine natural productsMolluscVermetidWorm snail

Identifiers

PMID42766257

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.