ArticleWorld journal of microbiology & biotechnology2026
Multifaceted biological activities of linalool: antimicrobial, antibiofilm, cytotoxic, antiproliferative and caspase-3/7 activity.
Article in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Linalool is a natural bioactive monoterpene with antimicrobial, antibiofilm, and anticancer potential. Its multifaceted biological activity was investigated using microbial and mammalian cell-based models, addressing the limited integrated characterization of these effects. In this study, the antimicrobial and antibiofilm efficacy of linalool was evaluated against selected pathogens, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, methicillin-resistant S.aureus (MRSA), Klebsiella pneumoniae, and Candida albicans. Its cytotoxic, antiproliferative, and morphological effects were evaluated in the C6 glioma cell line at concentrations of 25, 50, 100, 200, 400, and 800µM, together with assessment of caspase-3/7 activity as an apoptosis-related marker. Linalool exhibited antimicrobial activity against all tested microorganisms and significantly suppressed biofilm formation. Among the tested strains, S. aureus was the most susceptible pathogen, showing the lowest minimum inhibitory concentration (MIC) (414.8µM) and the highest biofilm inhibition (64.77%). MTT analysis showed that linalool exerted dose-dependent cytotoxicity in C6-glioma cells after 24 h, with an IC
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