Evidence map›Paper›PMID 42766173›Full record

ReviewCurrent allergy and asthma reports2026

Impact of Chronic Stress and Trauma on Asthma Pathophysiology and Outcomes.

Ryan Friedman, Anne DePrince, Elizabeth George, Sadhana Balasubramanyam, Eileen Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan FriedmanDivision of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, 1400 Jackson St, Denver, CO, 80206, USA.
Anne DePrinceDepartment of Psychology, University of Denver, 2155 S Race Street, Denver, CO, 80208, USA.
Elizabeth GeorgeDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35295, USA.
Sadhana BalasubramanyamDivision of Allergy and Immunology, Department of Medicine, Houston Methodist Hospital, 6155 Fannin St, Houston, TX, 77030, USA.
Eileen WangDivision of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, 1400 Jackson St, Denver, CO, 80206, USA. wange@njhealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewChronic stress and trauma are potent risk factors for worsened asthma outcomes. We summarize recent research discoveries surrounding chronic stress, adverse childhood experiences (ACEs), and intimate partner abuse (IPA) and their impacts on asthma pathophysiology and outcomes. We also highlight treatment and precision medicine implications. RECENT

findingsChronic stress and trauma have distinct yet persistent effects on asthma pathophysiology through multiple pathways, including the hypothalamic-pituitary-adrenal axis, neuroimmune signaling, central nervous system activity, and immune shifts. New research highlights stress and trauma's strong associations with increased asthma morbidity. Improvements in the understanding of underlying mechanisms highlight the potential of tailored or novel interventions. Despite significant leaps in our understanding of chronic stress and trauma's pervasive and enduring impacts on asthma, key actions-including clinical screening and broader inclusion in research-remain deficient. Improved recognition paired with targeted therapies offers the opportunity to improve the lives of many who are disproportionately burdened with increased asthma morbidity.

Indexed as

AsthmaStress, PsychologicalAdverse Childhood ExperiencesChronic DiseaseHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemRisk FactorsAdverse childhood experiencesAsthma outcomesAsthma pathophysiologyChronic stressIntimate partner abuseTrauma

Identifiers

PMID42766173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.