Safety and Tolerability of Early Minimal Enteral Nutrition from Birth in Preterm Neonates with Antenatal Doppler Abnormalities.

Pravin M, Ambalakkuthan Murugesan, Usha Devi R, Nishad Plakkal

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Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Pravin MJawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.

Ambalakkuthan MurugesanDepartment of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India. murugesan89@gmail.com.ORCID http://orcid.org/0000-0001-8052-1719

Usha Devi RDepartment of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.

Nishad PlakkalDepartment of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-for-gestational-age neonates with absent / reversal of end diastolic flow (AREDF) in umbilical artery doppler are at increased risk of perinatal complications. The authors conducted a retrospective cohort study in SGA neonates (≤34 wk) with AREDF to study the tolerability of early minimal enteral nutrition (MEN) initiated from birth, and compared the outcomes with those without AREDF. Out of 207 SGA neonates, 82 had AREDF. AREDF group had a significantly lower mean birth weight (1185 g vs. 1368 g; p <0.001) and a higher incidence of birth by caesarean section (85.4% vs. 60.8%, p < 0.0001). There was no difference in the primary outcome of feed intolerance [20.7% vs. 12.8%; RR 1.62 (0.87-3.02)]. Mortality, necrotizing enterocolitis (NEC), culture-proven sepsis were also similar between the groups. Multivariable logistic regression analysis revealed that gestational age and not AREDF status was associated with increased odds of feed intolerance.

Indexed as

Enteral NutritionUmbilical ArteriesEnterocolitis, NecrotizingFemaleGestational AgeHumansInfant, NewbornInfant, PrematureInfant, Small for Gestational AgeMalePregnancyRetrospective StudiesUltrasonography, DopplerUltrasonography, PrenatalAREDFFeed intoleranceNECSGA

Identifiers

PMID42766075

DOI10.1007/s12098-026-06411-6

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.