Evidence map›Paper›PMID 42765984›Full record

ArticleeLife2026

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism.

Yibing Bao, Zhenzi Zuo, Tengteng Wang, Lin Lin, Meng Gao, Shaogang Qin, Qingfeng Yang, Bingying Liu, Wanyuan Sun, Jie Ma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yibing BaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0007-6511-0234
Zhenzi ZuoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Tengteng WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Lin LinState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Meng GaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Shaogang QinState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Qingfeng YangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Bingying LiuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Wanyuan SunState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Jie MaDepartment of Gynecology, General Hospital of Ningxia Medical University, Ningxia, China.
Tianhua ZhuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Guoliang XiaState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Bo ZhouState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Rong HuReproductive Medicine Center, General Hospital of Ningxia Medical University, Ningxia, China.ORCID https://orcid.org/0000-0002-4859-6945
Hua ZhangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-4700-5971
Fengchao WangTransgenic Animal Center, National Institute of Biological Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-3595-2859
Chao WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0001-9923-3362

Funding

Innovative Project of State Key Laboratory of Animal Biotech Breeding 2024SKLAB 1-1National Key Research and Development Program of China 2022YFC2703803National Key Research and Development Program of China 2023YFD1300501National Key Research and Development Program of China 2024YFD1301001National Natural Science Foundation of China 32070839National Natural Science Foundation of China 32071132National Natural Science Foundation of China 32270904National Natural Science Foundation of China 32371167Natural Science Foundation of Beijing Municipality 7252085
6 · The paper itself

Abstract

The molecular mechanisms governing mRNA accumulation during oocyte growth, essential for developmental competence, remain poorly understood. This study investigates the role of Matrin-3 (MATR3), a highly expressed RNA-binding protein in growing oocytes (GOs), using oocyte-specific knockout mouse models and human oocyte maturation arrest (OMA) samples. The results showed that MATR3 was more abundant in GOs than fully grown oocytes (FGOs), highly expressed in the nucleus of non-surrounded nucleolus (NSN) oocytes, and exited the nucleus during the NSN-to-surrounded nucleolus (SN) transition. In OMA patients, MATR3 nuclear localization was missed, with smaller oocytes than FGOs. Further,

Indexed as

OocytesOogenesisRNA-Binding ProteinsAnimalsFemaleHumansMiceMice, KnockoutRNA-Binding Proteinsdevelopmental biologyepigenetic modificationfertilityfollicle developmentgrowing oocyteMatrin-3mouse

Identifiers

PMID42765984
PMCPMC13592816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.