Pathogenic Bordetella Bacteria Exploit Axonemal Microtubules to Penetrate the Ciliary Barrier.

Michael S Costello, Mia W Raimondi, Christopher S Hayes

Abstract read

In one paragraph

Article in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael S CostelloDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.

Mia W RaimondiDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.ORCID https://orcid.org/0009-0007-6902-0375

Christopher S HayesDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.ORCID https://orcid.org/0000-0002-2216-6445

Funding

Type 5 secretion as a novel mechanism to deliver protein effectors directly into mammalian host cellsR21AI191036 · NIAID · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI HAYES, CHRISTOPHER S. · 2025 to 2025

$410k

Investigation of the interaction of Bordetella FhaB adhesin with microtubulesR21AI185695 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI GONEN, SHANE, GOULDING, CELIA · 2024 to 2025

$403k

NIAID NIH HHS R21 AI185695NIAID NIH HHS R21 AI191036NIH HHS AI185695 and AI191036

6 · The paper itself

Abstract

Respiratory pathogens face a daunting physical challenge during host colonization. Invading microbes must resist elimination by motile respiratory cilia, which beat continuously to sweep debris from the airways. Bacteria have long been known to use adhesive proteins to bind host cells, but recent work shows that Bordetella species utilize an unusual strategy to colonize respiratory epithelia. Bordetella deploy FhaB adhesins that translocate a novel microtubule-binding domain into cilia to interact with the axoneme. These findings reveal FhaB to be a unique adhesive factor that exploits the internal cytoskeleton to colonize a protected niche in the host respiratory tract.

Identifiers

PMID42765591

DOI10.1002/cm.70205

PMCPMC13653760

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.