Evidence map›Paper›PMID 42765558›Full record

ArticleFEBS open bio2026

The C-terminal truncated splicing variant of NK1R negatively modulates substance P-stimulated NK1R signaling.

Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong-Ik Hwang

Abstract read
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lan Phuong NguyenDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
Duc Trung NguyenDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0001-2866-2554
Minyoung ChoDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
Jihun KimDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
Soyeon InDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
Thai Uy NguyenDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
Sunghoon HurhDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
Beom Jin ParkDepartment of Radiology, College of Medicine Anam Hospital, Korea University, Seoul, Republic of Korea.
Jong-Ik HwangDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-0729-1782

Funding

Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) RS-2022-KH129263National Research Foundation (NRF) funded by the Ministry of Science and ICT (MSIT) 2022R1F1A1074216
6 · The paper itself

Abstract

Mammalian neurokinin 1 receptor (NK1R) exists as full-length (NK1L) and truncated (NK1S) splice variants. However, the functional role of NK1S remains controversial; therefore, we investigated their functional interplay. Using NanoBiT and co-immunoprecipitation, we demonstrate that NK1L and NK1S form heterodimeric complexes. Through this interaction, NK1S negatively modulates NK1L-mediated G protein signaling, specifically impairing Gαq coupling and Ca

Indexed as

migrationneurokinin 1 receptorreceptor dimerizationsplicing variantssubstance P

Identifiers

PMID42765558
PMCPMC13592011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.