Evidence map›Paper›PMID 42765537›Full record

ArticleJournal of medical virology2026

Eugenol-Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights.

Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adriana Cotta Cardoso ReisPharmacy School, Federal University of Ouro Preto, Ouro Preto, Brazil.ORCID https://orcid.org/0000-0002-7368-3573
Amália Luíza de Sousa da SilvaPharmacy School, Federal University of Ouro Preto, Ouro Preto, Brazil.
Camila PortruneliPharmacy School, Federal University of Ouro Preto, Ouro Preto, Brazil.
Augusto Vieira Pontes SilvaPharmacy School, Federal University of Ouro Preto, Ouro Preto, Brazil.
Saulo Fehelberg Pinto BragaPharmacy School, Federal University of Ouro Preto, Ouro Preto, Brazil.ORCID https://orcid.org/0000-0003-3218-3107
Igor Rodrigues LapaDepartment of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, Brazil.
Thiago Belarmino de SouzaPharmacy School, Federal University of Ouro Preto, Ouro Preto, Brazil.ORCID https://orcid.org/0000-0003-3627-6407
Lucas Lopardi FrancoDepartment of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, Brazil.
Diogo Teixeira CarvalhoDepartment of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, Brazil.ORCID https://orcid.org/0000-0002-6362-2822
Geraldo Célio BrandãoPharmacy School, Federal University of Ouro Preto, Ouro Preto, Brazil.ORCID https://orcid.org/0000-0002-7330-051X

Funding

Conselho Nacional de Desenvolvimento CientÍfico e TecnolÓgico 305476/2025-4Conselho Nacional de Desenvolvimento CientÍfico e TecnolÓgico 402010/2023-0FundaÇÃo de Amparo À Pesquisa do Estado de Minas Gerais APQ-01375-24FundaÇÃo de Amparo À Pesquisa do Estado de Minas Gerais APQ-01455-24FundaÇÃo de Amparo À Pesquisa do Estado de Minas Gerais APQ-06528-24FundaÇÃo de Amparo À Pesquisa do Estado de Minas Gerais BPD-00381-22FundaÇÃo de Amparo À Pesquisa do Estado de Minas Gerais RED-00110-23FundaÇÃo de Amparo À Pesquisa do Estado de Minas Gerais RED-00170-23Universidade Federal de Ouro Preto 23109.007219/2024-11
6 · The paper itself

Abstract

Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical. This study evaluated sixteen eugenol- and dihydroeugenol-derived piperazine Mannich bases for antiviral activity against CHIKV, MAYV, and Zika virus (ZIKV) in Vero cells. Cytotoxicity was assessed using the MTT assay, and antiviral activity was quantified through median effective concentration (EC

Indexed as

AlphavirusAntiviral AgentsEugenolPiperazinesAnimalsCell SurvivalChikungunya virusChlorocebus aethiopsCytopathogenic Effect, ViralMannich BasesMolecular Docking SimulationVero CellsViral Plaque AssayZika VirusAntiviral AgentsEugenolMannich BasesPiperazinesantiviral activityArbovirusesChikungunya viruseugenol derivativesMayaro viruspiperazine Mannich bases

Identifiers

PMID42765537
PMCPMC13591657

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.