SynthesisDiabetes/metabolism research and reviews2026
Metabolic Dysfunction-Associated Steatotic Liver Disease in Adults With Acromegaly: A Meta-Analysis of Observational Studies.
Synthesis in Diabetes/metabolism research and reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
aimsAcromegaly is a chronic, progressive disease characterised by excess growth hormone secretion and elevated circulating insulin-like growth factor 1 levels. Data on hepatic fat content and liver stiffness in adults with active or controlled acromegaly remain inconsistent.
methodsWe systematically searched PubMed and Scopus from inception through 15 June 2026 to identify studies comparing hepatic steatosis and liver stiffness in adults with acromegaly and in controls. Hepatic fat content was quantified using magnetic resonance imaging (MRI)-based techniques, and liver stiffness was assessed using vibration-controlled transient elastography or other elastography methods. Pooled effect sizes were reported as weighted mean differences (WMDs) with 95% confidence intervals.
resultsWe identified 9 observational studies, including 190 patients with acromegaly and 235 age-, sex-, and BMI-matched controls. Compared with controls, patients with acromegaly had significantly lower hepatic fat content, as assessed by MRI-based techniques (six studies; random-effects WMD -3.04% [95% CI -4.81 to -1.26%]; I
conclusionsOur meta-analysis suggests that patients with acromegaly have significantly lower hepatic fat content than controls, particularly among those with active disease, whereas liver stiffness does not appear to differ significantly between the groups.
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