ArticleVeterinary world2026
Niemann-Pick type C2-mediated cholesterol sequestration induces capacitation-like sperm remodeling during reproductive tract transit in the blue swimming crab (Portunus pelagicus).
Article in Veterinary world, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aim: Cholesterol (CHO) sequestration from the sperm plasma membrane is a fundamental event during mammalian sperm capacitation, but the molecular mechanisms underlying capacitation-like sperm activation in brachyuran crabs remain unknown. Although Niemann-Pick type C2 (NPC2), a high-affinity CHO-binding protein, has been implicated in sperm maturation in penaeid shrimp, its occurrence and physiological role in brachyuran species have not been investigated. This study characterized the Materials and Methods: The Results: Conclusion: This study provides the first molecular and functional characterization of NPC2 in a brachyuran crab and demonstrates that NPC2-mediated CHO sequestration is a conserved mechanism driving capacitation-like sperm activation during reproductive tract transit. These findings expand current understanding of reproductive biology in marine crustaceans and provide a molecular foundation for future studies on sperm preservation, assisted reproduction, and crustacean aquaculture.
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