Evidence map›Paper›PMID 42765111›Full record

ArticleJHLT open2026

Infections following temporary mechanical circulatory support in cardiogenic shock: Incidence, associations, and outcomes.

Neil Shah, Gavin W Hickey, Eun Jeong Kwak, Jianhui Zhu, Floyd Thoma, Raj Ramanan, Mark Schmidhofer, David Kaczorowski, Mohamed Abdullah, Holt Murray and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Neil ShahHeart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Gavin W HickeyHeart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Eun Jeong KwakDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jianhui ZhuHeart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Floyd ThomaHeart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Raj RamananDepartment of Critical Care Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Mark SchmidhoferHeart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
David KaczorowskiDepartment of Cardiothoracic Surgery, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Mohamed AbdullahDepartment of Cardiothoracic Surgery, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Holt MurrayDepartment of Critical Care Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Jonathan D WolfeHeart and Vascular Institute, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Ryan M RivosecchiDepartment of Pharmacy, UPMC Presbyterian, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Infection complicates temporary mechanical circulatory support (tMCS) in cardiogenic shock (CS), but the contributions of device, severity, and timing remain unclear. Methods: Adults with CS supported by Impella, venoarterial extracorporeal membrane oxygenation (VA-ECMO), or both (ECPELLA) at a quaternary center (2021-2025) were studied retrospectively. Infection required clinician diagnosis, positive culture, and ≥5 days of targeted therapy. Cause-specific Cox and Fine-Gray competing-risks models assessed infection and a separate Cox model assessed 60-day mortality with infection as a time-varying covariate. Results: Among 297 patients, 111 (37.4%) developed a post-tMCS infection. Most first infections (75.7%) occurred within 14 days, with week-1 incidence over twice the average. Infected patients had longer hospital stays (35 vs 19 days, Conclusions: Infection affected more than one-third of CS-tMCS patients, with peak risk in the first week. VA-ECMO support carried higher infection risk. Sixty-day mortality tracked older age and lactate at tMCS placement, but not device type. Infection was not associated with increased mortality but was associated with longer hospitalization and worse discharge disposition.

Indexed as

cardiogenic shockextracorporeal membrane oxygenationImpellanosocomial infectionoutcomestemporary mechanical circulatory support

Identifiers

PMID42765111
PMCPMC13590069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.