ArticleVeterinary world2026
Coenzyme Q10 supplementation enhances HSP70 gene expression and preserves mitochondrial function in cryopreserved Peranakan Ettawa goat spermatozoa.
Article in Veterinary world, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aim: Cryopreservation is essential for the long-term preservation and dissemination of superior goat genetics but induces oxidative, osmotic, and thermal stress that compromises sperm quality and fertilizing potential. Mitochondrial dysfunction, lipid peroxidation, and impaired cellular stress responses are major contributors to cryoinjury. Coenzyme Q10 (CoQ10), a mitochondrial electron carrier and potent lipid-soluble antioxidant, has been proposed as a cryoprotective supplement; however, its effects on heat shock protein 70 ( Materials and Methods: Semen was collected from one clinically healthy 4-year-old PE buck, and eight independent ejaculates were processed using a split-ejaculate design. Each ejaculate was divided into five treatment groups supplemented with CoQ10 at 0 (C0), 5 (C1), 10 (C2), 20 (C3), and 40 mg/dL (C4). Following cryopreservation and thawing, Results: CoQ10 supplementation significantly improved all evaluated post-thaw parameters (p < 0.001). The C4 group exhibited the highest Conclusion: Supplementation of Extender A with CoQ10 effectively enhanced post-thaw quality of PE goat spermatozoa by preserving mitochondrial function, improving sperm viability, and upregulating
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