Evidence map›Paper›PMID 42765007›Full record

ArticleActa pharmaceutica Sinica. B2026

Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution.

Stephan Permann, Elena Brunner, Khaled Alsabil, Markus Werner, Lorenz Waltl, Guillaume Viault, Danilo D'Avino, Bill Perkowski, Anita Siller, Laura Fritsch and 11 more

Abstract read
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In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Stephan PermannMichael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.
Elena BrunnerDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
Khaled AlsabilUniv Angers, SONAS, SFR QUASAV, Angers 49000, France.
Markus WernerDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
Lorenz WaltlMichael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.
Guillaume ViaultUniv Angers, SONAS, SFR QUASAV, Angers 49000, France.
Danilo D'AvinoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy.
Bill PerkowskiDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
Anita SillerCentral Institute for Blood Transfusion and Immunology, Tirol Kliniken GmbH, Innsbruck 6020, Austria.
Laura FritschDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
Sara PernaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy.
Harald SchennachCentral Institute for Blood Transfusion and Immunology, Tirol Kliniken GmbH, Innsbruck 6020, Austria.
Denis SéraphinUniv Angers, SONAS, SFR QUASAV, Angers 49000, France.
Solveigh C KoeberleInstitute of Pharmaceutical Sciences and Excellence Field BioHealth, NAWI Graz, University of Graz, Graz 8010, Austria.
Paul M JordanDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
Fiorentina RoviezzoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy.
Pascal RichommeUniv Angers, SONAS, SFR QUASAV, Angers 49000, France.
Antonietta RossiDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy.
Jean-Jacques HelesbeuxUniv Angers, SONAS, SFR QUASAV, Angers 49000, France.
Oliver WerzDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
Andreas KoeberleMichael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restoring homeostasis in persistent inflammation requires suppressing the inflammatory response and promoting resolution. Currently, no clinically used small molecules intentionally achieve both effects. Endogenous long-chain vitamin E metabolites (LCMs) address inflammation at multiple sites, including pro-inflammatory leukotriene production and cytokine release, thus limiting inflammation. Among LCMs, we here identified

Indexed as

FerroptosisInflammationLipid mediatorLipoxygenaseProtectinResolutionVitamin E

Identifiers

PMID42765007
PMCPMC13589943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.