ArticleMolecular therapy. Advances2026
Automated zonal-rotor CsCl ultracentrifugation with ÄKTA-based fractionation removes empty and intermediate AAV capsids.
Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Recombinant adeno-associated virus (AAV) preparations contain heterogeneous full, empty, and intermediate capsids. Although anion-exchange chromatography is scalable, it does not always resolve these populations, particularly intermediate capsids. A workflow integrated zonal-rotor cesium chloride (CsCl) density-gradient ultracentrifugation with ÄKTA-based loading, inline monitoring, unloading, and fraction collection. SW41Ti swing-bucket experiments defined the empirical 1,240-1,360 mg/cm
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