ArticleBreast cancer (Dove Medical Press)2026
Development of a Consensus-Based Risk Stratification Algorithm for HR+/HER2- Early Breast Cancer to Guide Adjuvant CDK4/6i Therapy: Outcomes from a Multidisciplinary Workshop in India.
Article in Breast cancer (Dove Medical Press), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer (EBC) is treated with curative intent, but risk of recurrence (RoR) remains a challenge. The identification of high RoR EBC patients is inconsistent, highlighting the need for a simplified approach. This study aimed to develop an evidence-informed, consensus-based tool to support recurrence risk stratification and treatment decision-making in patients with HR+/HER2- EBC, incorporating multidisciplinary perspectives and evolving evidence from guidelines and trials. Methods: Five structured, multidisciplinary workshops were conducted across India, involving 135 experts, to integrate evidence and expert consensus into a practical algorithm for RoR assessment. The workshops included initial polling on clinical practices, followed by case-based discussions and literature review, with post-discussion polling used to capture shifts in expert perspectives. Results: Polling responses demonstrated consensus (defined as ≥70% agreement by experts) that all N1 patients are at a high RoR (94.3%) and that tumors ≥5 cm are associated with high risk (90.0%). Given that low-grade (G1) tumors are associated with a favorable prognosis (low risk) and high-grade (G3) tumors indicate a poorer prognosis (high risk), Ki-67-based treatment decision-making was considered most relevant for the moderate-grade (G2) subgroup. Accordingly, experts agreed that combining tumor grade G2 with Ki-67 assessment improves risk stratification in N0 patients with tumors <5 cm (71.6%). A Ki-67 cut-off of ≥20% was considered critical (96.3%). The experts agreed that adjuvant cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have an invasive disease-free survival (iDFS) advantage in all N1 (93.8%) and high risk N0 (91.1%) patients with HR+/HER2- EBC. Conclusion: The developed algorithm provides a user-friendly framework to facilitate uniform risk stratification and optimize HR+/HER2- EBC treatment in India. Further prospective and real-world validation is required to establish its clinical utility and evaluate its impact on treatment decisions.
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