Evidence map›Paper›PMID 42764912›Full record

ArticleActa pharmaceutica Sinica. B2026

Neuroprotection by YZG-331 in postoperative cognitive dysfunction

Han Guo, Jiaojiao Zhao, Keying Tian, Qinghui Guo, Siruan Chen, Yuhan Ge, Wenyan Guo, Xingchen Lin, Hui Bai, Lei Yang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Han GuoDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Jiaojiao ZhaoDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Keying TianDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Qinghui GuoDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Siruan ChenDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Yuhan GeModel Animal Research Center, Medical School, Nanjing University, Nanjing 210032, China.
Wenyan GuoDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Xingchen LinGuangdong Institute of Intelligence Science and Technology, Zhuhai 519031, China.
Hui BaiDepartment of Cardiac Ultrasound, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Lei YangSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Lei YangDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Xia QinDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Panpan ZhangDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Zhanfeng JiaDepartment of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China.
Ruifang ZhengXinjiang Key Laboratory of Uygur Medical Research, Xinjiang Institute of Materia Medica, Urumqi 841100, China.
Zuxiao YangDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Yun Stone ShiModel Animal Research Center, Medical School, Nanjing University, Nanjing 210032, China.
Dezhi KongDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.
Tengfei JiInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wei ZhangDepartment of Pharmacology of Chinese Materia Medica, Institution of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei Medical University, Shijiazhuang 050017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative cognitive dysfunction (POCD) is a debilitating neurological complication that occurs following surgery, for which no effective interventions are currently available. Here, we identified YZG-331, a novel adenosine analog, as a promising neuroprotective agent that rescues cognitive deficits and mitigates dendritic spine loss in a murine POCD model. Integrated proteomic profiling and bioinformatics pathway analysis revealed that YZG-331 selectively targets NMDA receptor (NMDAR) signaling. Electrophysiological recordings and living-cell calcium imaging demonstrated that YZG-331 suppressed NMDAR-mediated currents and calcium influx in a dose-dependent manner. Furthermore, Mg

Indexed as

Cognitive functionMg2+NeuroprotectionNMDA receptorsPostoperative cognitive dysfunction (POCD)YZG-331

Identifiers

PMID42764912
PMCPMC13590013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.