Evidence map›Paper›PMID 42764882›Full record

ArticleIranian journal of medical sciences2026

Differential Expression of Visfatin, Sirtuin-1, and Interleukin-18 in Ankylosing Spondylitis Patients: A Comparative Study of Etanercept-Treated versus Newly Diagnosed Patients.

Afrouz Asgarian, Zahra Hesari, Mehrdad Aghaei, Zahra Faghhian, Romina Malakouti, Sima Besharat, Koushan Sineh Sepehr

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Afrouz AsgarianClinical Research Development Unit, Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
Zahra HesariMetabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran.
Mehrdad AghaeiGolestan Rheumatology Research Center, Biomedical Research Institute, Golestan University of Medical Science, Gorgan, Iran.
Zahra FaghhianMetabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran.
Romina MalakoutiLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Sima BesharatGolestan Research Center of Gastroenterology and Hepatology, Jorjani Clinical Sciences Research Institute, Golestan University of Medical Sciences, Gorgan, Iran.
Koushan Sineh SepehrLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial joints. In response to inflammation, sirtuin-1 ( Methods: In 2022, this cross-sectional study was conducted in Gorgan, Iran. Peripheral blood mononuclear cells (PBMCs) were isolated from a total of 49 AS patients, including patients undergoing treatment with three doses of etanercept and the newly diagnosed, treatment-naïve patients. Total RNA was extracted from PBMCs, and complementary DNA (cDNA) was synthesized. Gene expression levels of Results: Conclusion: Etanercept significantly upregulates SIRT-1 expression while suppressing IL-18 and visfatin levels in AS patients, highlighting its pleiotropic anti-inflammatory mechanisms beyond TNF-α blockade. These findings provide novel insights into the molecular pathways modulated by anti-TNF therapy, particularly the interplay between

Indexed as

CytokinesEtanerceptInterleukin-18Nicotinamide PhosphoribosyltransferaseSirtuin 1Spondylitis, AnkylosingAdultCross-Sectional StudiesFemaleHumansIranLeukocytes, MononuclearMaleMiddle AgedCytokinesEtanerceptIL18 protein, humanInterleukin-18Nicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanSIRT1 protein, humanSirtuin 1Ankylosing SpondylitisEtanerceptIL-18SIRT-1Visfatin

Identifiers

PMID42764882
PMCPMC13589817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.