ArticleClinical, cosmetic and investigational dermatology2026
Clinicopathologic Features and Outcomes of Basal Cell Carcinoma Coexisting with Other Tumors or Precancerous Lesions: A Single-Center Analysis.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Objective: To characterize the clinicopathologic spectrum, treatment patterns, and outcomes of basal cell carcinoma (BCC) coexisting with other tumors or precancerous lesions. Methods: We retrospectively reviewed pathologically confirmed cases diagnosed at Peking Union Medical College Hospital between 2020 and 2025. Demographic, clinical, histopathologic, treatment, and outcome data were extracted and analyzed. Results: Among 860 pathologically confirmed BCC cases, 17 met the inclusion criteria. The cohort comprised 9 women (52.9%) and 8 men (47.1%), with a mean age of 56.71 ± 21.14 years. Coexisting lesions were classified as hamartoma/nevus-associated (7 cases), keratinocytic lesion-associated (5 cases), or adnexal/cyst-associated (5 cases). Nevus sebaceus was the most frequent coexisting lesion. All lesions involved the head and neck, and 16 (94.1%) showed recent enlargement or another new change on a preexisting lesion. Nodular and superficial BCC predominated. Exploratory comparison with a contemporary head and neck BCC cohort suggested that the present cohort was characterized by younger age, more frequent scalp/frontotemporal involvement, enrichment of superficial BCC, and fewer aggressive subtypes. Most patients had favorable outcomes without recurrence or metastasis observed. Conclusion: BCC coexisting with other tumors or precancerous lesions has a distinct clinicopathologic profile, and often presents as recent changes in a long-standing head/neck lesion. Classification by coexisting lesion type may help integrate clinical morphology, pathology, and risk assessment.
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