ArticleIranian journal of medical sciences2026
High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study.
Article in Iranian journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Monounsaturated fatty acids (MUFAs) are dietary and circulating fats that may influence cardiovascular health. However, their causal role in cardiovascular diseases (CVDs) remains unclear due to conflicting observational evidence. This study aimed to determine the causal relationship of high serum MUFAs with the risk of various CVDs using the Mendelian randomization (MR) design. Methods: The summary statistics dataset related to serum MUFAs was used from the published genome-wide association study (GWAS) of European descent in UK Biobank participants (n=114,999). Genetic variants underlying angina, atherosclerotic, ischemic heart disease (IHD), myocardial infarction (MI), and hypertension events were ascertained using a GWAS dataset of 461,880 (case=14,828, control=447,052), 463,010 (case=12,171, control=450,839), 361,194 (case=20,857, control=340,337), 462,933 (case=10,616, control=452,317), and 461,880 (case=124,227, control=337,653) European descent participants from the UK Biobank, respectively. We investigated potential association relationships between MUFAs and these outcomes using generalized summary Mendelian randomization (GSMR) and two-sample Mendelian randomization (TSMR). TSMR was employed to validate associations identified by GSMR. The results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: GSMR results showed that MUFAs were associated with angina (OR=1.007, 95%CI:1.005-1.009; P<0.001), atherosclerotic (OR=1.006, 95%CI:1.004-1.008; P<0.001), IHD (OR=1.006, 95%CI:1.003-1.009; P<0.001), MI (OR=1.003, 95%CI:1.001-1.005; P<0.001), and hypertension (OR=1.003, 95%CI:0.998-1.008; P<0.001). Besides, TSMR results indicated that MUFAs were associated with angina (OR=1.012, 95%CI:1.010-1.015), atherosclerotic (OR=1.009, 95%CI:1.006-1.011; P<0.001), IHD (OR=1.015, 95%CI:1.010-1.019; P<0.001), MI (OR=1.007, 95%CI:1.004-1.009; P<0.001), and hypertension (OR=1.021, 95%CI:1.011-1.031; P<0.001). These findings remained consistent when utilizing different MR methods and sensitivity analyses. Conclusion: The current MR study indicated that higher levels of MUFAs might be associated with an increased risk of CVD events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.