Unspecific Peroxygenase-Based Chemo-Enzymatic Synthesis of Amino Alcohols for Pharmaceutical Preparation.

Simon Last, Alina Gazizova, Katharina Wittmann, Niklas Dietz, Martin J Weissenborn, Jan von Langermann

Abstract read

In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Simon LastInstitute for Chemistry, Biocatalysis Group, Otto-von-Guericke-University, Magdeburg, Germany.ORCID https://orcid.org/0009-0005-8862-4209

Alina GazizovaInstitute for Chemistry, Biocatalysis Group, Otto-von-Guericke-University, Magdeburg, Germany.

Katharina WittmannInstitute for Chemistry, Biocatalysis Group, Otto-von-Guericke-University, Magdeburg, Germany.

Niklas DietzInstitute of Chemistry, Organic Chemistry Group, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.

Martin J WeissenbornInstitute of Chemistry, Organic Chemistry Group, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.ORCID https://orcid.org/0000-0002-1200-4485

Jan von LangermannInstitute for Chemistry, Biocatalysis Group, Otto-von-Guericke-University, Magdeburg, Germany.ORCID https://orcid.org/0000-0001-9302-9803

Funding

Deutsche Forschungsgemeinschaft 450014604Deutsche Forschungsgemeinschaft 505185500

6 · The paper itself

Abstract

This study explores the use of unspecific peroxygenases for the enantioselective preparation of amino alcohol-based pharmaceuticals and their respective precursors. The aim of this work was to develop a practical concept by simplifying the otherwise complex synthesis approach, thereby expanding the application of unspecific peroxygenases toward chemo-enzymatic synthesis. To introduce hydroxy groups at specific positions within protected amines, the unspecific peroxygenase (UPO) was used, which facilitated the enantioselective synthesis toward shorter overall reaction pathways and thus may serve as an addition to the preparative toolbox with this type of enzyme.

Indexed as

Amino AlcoholsMixed Function OxygenasesStereoisomerismAmino AlcoholsMixed Function Oxygenasesperoxygenaseamino alcoholsbuilding blockschemo‐enzymatic conversionpharmaceuticalsunspecific peroxygenase

Identifiers

PMID42764703

DOI10.1002/cbic.70537

PMCPMC13591206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.