Evidence map›Paper›PMID 42764684›Full record

SynthesisPain research & management2026

Does Auricular Acupoint-Related Therapy Enhance Rehabilitation After Total Knee Arthroplasty? A Systematic Review and Network Meta-Analysis.

Qindong Mi, Yunxi Xu, Fei Bao, Xiaolong Zhao, Lijin Liu, Zhihong Wu

Abstract readSystematic ReviewNetwork Meta-Analysis
In one paragraph

Synthesis in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qindong MiDepartment of TCM, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China, cams.ac.cn.ORCID https://orcid.org/0009-0003-8578-2952
Yunxi XuDepartment of Ophthalmology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China, scu.edu.cn.ORCID https://orcid.org/0009-0006-4985-3778
Fei BaoDepartment of TCM, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China, cams.ac.cn.ORCID https://orcid.org/0000-0002-6508-2583
Xiaolong ZhaoDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China, pumch.cn.ORCID https://orcid.org/0009-0000-6446-1015
Lijin LiuStem Cell Facility, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China, cams.ac.cn.ORCID https://orcid.org/0009-0005-5545-2842
Zhihong WuStem Cell Facility, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China, cams.ac.cn.ORCID https://orcid.org/0000-0002-1902-4198

Funding

National High-Level Hospital Clinical Research Funding 2025-PUMCH-C-002Peking Union Medical College Hospital ZC201903189
6 · The paper itself

Abstract

backgroundAlthough auricular acupoint-related therapy (AART) is increasingly used for postoperative rehabilitation after total knee arthroplasty (TKA), evidence comparing the effectiveness of different AART modalities remains limited. This study aimed to evaluate the efficacy and safety of AART through a systematic review and network meta-analysis (NMA).

methodsWe performed a systematic review and NMA of randomized controlled trials (RCTs) from multiple Chinese and English databases, from inception to June 2026. Two reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane ROB-2 tool and evidence quality with GRADE. Pairwise comparisons and NMA were conducted using RevMan 5.4 and R software.

resultsTwenty-four RCTs involving 1790 patients were included. Compared with routine rehabilitation, AART significantly reduced resting pain scores on postoperative day 1 (mean difference [MD] = -0.38) and day 3 (MD = -0.61) and improved movement-evoked pain on days 3 and 7. AART also enhanced knee function (Hospital for Special Surgery scores), increased active range of motion, and reduced complications such as vomiting, dizziness, and urinary retention. NMA suggested that auricular acupressure combined with Chinese medicine transdermal therapy may be the most effective intervention for early resting pain. Of note, the certainty of evidence for most outcomes was low or very low, and the findings should be interpreted with caution in clinical practice, serving only as preliminary reference rather than definitive clinical guidance.

conclusionAART may serve as an effective non-pharmacological adjunct in multimodal rehabilitation after TKA, particularly for acute pain relief, functional recovery, and complication reduction. High-quality trials are needed to confirm these findings.

Indexed as

Acupuncture, EarAcupuncture PointsArthroplasty, Replacement, KneePostoperative PainHumansRandomized Controlled Trials as Topicauricular acupoint-related therapyfunctional recoverypain managementpostoperative rehabilitationtotal knee arthroplasty

Identifiers

PMID42764684
PMCPMC13591118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.