Evidence map›Paper›PMID 42764605›Full record

ArticleChemistry & biodiversity2026

Fatty Acid Composition of Fixed Oil of Linum strictum and Its Antibiofilm, Anticoagulant, and α-Amylase Inhibitory Effects-In Vitro and In Silico Study.

Hayet Edziri, Pooja Bargali, Marwa Melliti, Hasan Aljohi, Mohammad NasserAlkhrayef, Rim Gtari, Marcello Iriti, Ravendra Kumar, Ibrahim O Alanazi

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hayet EdziriLaboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.ORCID https://orcid.org/0000-0003-2905-8129
Pooja BargaliDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, U.S. Nagar, Uttarakhand, India.ORCID https://orcid.org/0009-0006-3419-5119
Marwa MellitiLaboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.ORCID https://orcid.org/0009-0001-4858-2172
Hasan AljohiApplied Genetics Technology Institute, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Mohammad NasserAlkhrayefDisability Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia.ORCID https://orcid.org/0009-0006-1520-9941
Rim GtariLaboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
Marcello IritiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-5063-1236
Ravendra KumarDepartment of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, U.S. Nagar, Uttarakhand, India.ORCID https://orcid.org/0000-0002-0296-5231
Ibrahim O AlanaziThe Healthy Aging Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-8479-7875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigated the fatty acid composition of Linum strictum seed oil and evaluated its antibacterial, antibiofilm, anticoagulant, and α-amylase inhibitory activities. The oil was extracted from commercially obtained seeds and characterized by GC-FID. Antibacterial activity was determined using the microbroth dilution method, while antibiofilm activity was assessed against multidrug-resistant strains, including Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA), and Acinetobacter baumannii. Anticoagulant effects were evaluated using prothrombin time (PT) and activated partial thromboplastin time (aPTT), and α-amylase inhibition was assessed in vitro. The oil was characterized by a high proportion of unsaturated fatty acids, mainly α-linolenic (57.08%), oleic (17.53%), and linoleic (14.0%) acids. Significant antibacterial activity was observed against Enterococcus faecalis ATCC 29212 and A. baumannii A2553 and A722 (MIC = 1.25 mg/mL), while three S. aureus strains showed MIC values of 5 mg/mL. Biofilm inhibition exceeded 70% against A. baumannii at 2×MIC. The oil prolonged coagulation times, particularly through the intrinsic pathway (PT = 16.4 s; aPTT = 81.6 s). α-Amylase inhibition reached 85.98% (IC

Indexed as

alpha-AmylasesAnti-Bacterial AgentsAnticoagulantsBiofilmsEnzyme InhibitorsFatty AcidsFlaxPlant OilsAcinetobacter baumanniiMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular Docking SimulationPseudomonas aeruginosaSeedsalpha-AmylasesAnti-Bacterial AgentsAnticoagulantsEnzyme InhibitorsFatty AcidsPlant OilsantibacterialantibiofilmanticoagulationLinum strictummolecular dockingmulti‐resistant bacteriaseed oilα‐amylase

Identifiers

PMID42764605
PMCPMC13591068

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.