ArticleChemistry & biodiversity2026
Anti-Inflammatory Activity of Capparis cartilaginea Decne. Essential Oil and Its Main Constituents via Modulation of the NLRP3 Inflammasome.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Capparis cartilaginea Decne. (C. cartilaginea) is traditionally used for the management of inflammatory conditions; however, the contribution of its volatile constituents to these effects remains poorly understood. This study evaluated the anti-inflammatory activity of the essential oil of C. cartilaginea and its major constituents, isopropyl isothiocyanate and 2-methylbutanenitrile, using an in vitro model of lipopolysaccharide (LPS)-induced inflammation in THP-1 human macrophages. The essential oil and its main constituents significantly reduced cytokine release and nitric oxide (NO) production compared with LPS-stimulated controls. These effects were associated with modulation of the NLRP3 inflammasome and inhibition of caspase-1 activation, partly mediated through MAPK-dependent pathways. In addition, treatment significantly inhibited NF-κB activation and phosphorylation. Overall, these findings demonstrate that the volatile fraction contributes to the anti-inflammatory activity of C. cartilaginea, providing mechanistic support for its traditional use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.