Evidence map›Paper›PMID 42764380›Full record

ArticleJournal of intensive care2026

Pathogen-oriented mNGS is not equivalent to microbiome profiling: interpreting BALF mNGS diversity in ARDS.

Li Li, Song Lei, Chansokhon Ngan

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Li Li *Department of Critical Care Medicine, Affiliated Hospital of Sichuan Nursing Vocational College, The Third People's Hospital of Sichuan Province, Chengdu, Sichuan, China.
Song Lei *Department of Critical Care Medicine, Affiliated Hospital of Sichuan Nursing Vocational College, The Third People's Hospital of Sichuan Province, Chengdu, Sichuan, China.
Chansokhon NganYunnan Chinese Language and Culture College, Yunnan Normal University, No. 768, Juxian Street, Chenggong District, Kunming, Yunnan, China. sokhon@126.com.ORCID https://orcid.org/0000-0001-5142-0089

Funding

Health Commission of Sichuan Province Medical Science and Technology Program 25LCYJ34
6 · The paper itself

Abstract

Gao et al. provide valuable data-linking bronchoalveolar lavage fluid metagenomic next-generation sequencing with inflammatory subphenotypes of acute respiratory distress syndrome. We highlight three issues relevant to interpretation: an apparent inconsistency concerning exclusion of samples with no micro-organisms detected, use of a pathogen-oriented workflow for community-level ecological inference, and the distinction between detection yield and diagnostic performance without an independent reference standard. Clarification of sample eligibility, sensitivity analysis including technically valid samples reported as negative by sequencing, and confirmation that sequencing and bioinformatic procedures are validated for quantitative microbiome analysis would strengthen interpretation.

Indexed as

Acute respiratory distress syndromeBronchoalveolar lavage fluidMetagenomic next-generation sequencingMicrobial diversityPulmonary microbiome

Identifiers

PMID42764380
PMCPMC13589869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.