ArticleHealth and quality of life outcomes2026
Changes in health-related quality of life: a longitudinal registry study among over 15,000 participants of a digital education and exercise therapy for knee and hip osteoarthritis using EQ-5D-5L.
Article in Health and quality of life outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo explore changes in health-related quality of life (HRQoL) measured using EQ-5D-5L among participants of a digital education and exercise therapy for knee and hip osteoarthritis (OA).
methodsA descriptive longitudinal registry-based study among participants aged 40 + years enrolled in the digital program with responses to EQ-5D-5L at enrolment and at least one follow-up at 3- [n = 15147] or 12-months [n = 4586]. Changes in EQ-5D-5L profile from enrolment were examined using the Paretian classification of health change (PCHC).
resultsAt enrolment, selfcare and pain/discomfort were the EQ-5D-5L dimensions with the least and most reported problems, respectively. The percentages of participants reporting improvements in EQ-5D-5L dimensions ranged from 12.9% (14.0%) for selfcare to 33.0% (38.4%) for pain/discomfort at 3 (12) months follow-ups. The corresponding percentages in reporting worsening ranged from 8.0% for selfcare to 15.4% for usual activities at 3 months and from 10.0% for selfcare to 16.4% for mobility at 12 months. At all timepoints, "slight problems" in the pain/discomfort dimension and no problems in other dimensions (the EQ-5D-5L profile "11121") was the most common profile. The PCHC analysis suggested that at 3/12 months follow-ups, the EQ-5D-5L profiles improved for 46.9%/50.4% of participants, worsened for 19.5%/20.1%, showed mixed changes for 19.7%/18.7% and remained unchanged for 13.9%/10.9%.
conclusionIn this single-arm registry study, about half of participants reported improved EQ-5D-5L profiles at 3 and 12 months following digital education and exercise therapy, while one-fifth reported worsening and another one-fifth showed mixed changes, indicating heterogeneous HRQoL trajectories and the need for tailored participant support.
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