Evidence map›Paper›PMID 42764346›Full record

ArticleNature communications2026

Deep learning for precision grading of Schistosoma japonicum-induced liver fibrosis in ultrasound images.

Ziyang Xu, Jianfeng Zhang, Tingting Wu, Haiyong Hua, Kun Yang, Tieyong Zeng

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ziyang XuDepartment of Mathematics, The Chinese University of Hong Kong, Hong Kong, China.
Jianfeng ZhangJiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Tingting WuSchool of Science, Nanjing University of Posts and Telecommunications, Nanjing, China.ORCID http://orcid.org/0000-0002-9880-8619
Haiyong HuaJiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Kun YangJiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Institute of Parasitic Diseases, Wuxi, China. yangkun@jipd.com.ORCID http://orcid.org/0000-0001-8198-132X
Tieyong ZengInstitute for Advanced Study, Beijing Normal-Hong Kong Baptist University, Zhuhai, China. tieyongzeng@bnbu.edu.cn.ORCID http://orcid.org/0000-0002-0688-202X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82173586, 82373644
6 · The paper itself

Abstract

Liver fibrosis caused by schistosomiasis is a major health problem in endemic regions. Ultrasonography is widely used for screening, but grading remains subjective and dependent on specialist expertise. Here we show that a deep learning system can provide automated, fine-grained assessment of liver fibrosis caused by Schistosoma japonicum. We developed and evaluated the system using a multicentre dataset of 167,702 ultrasound images labelled on a 36-level scale from 0.0 to 3.5, designed to capture gradual disease progression and map onto four clinical grades. Of these images, 16,811 were reserved for the independent test set. In this test set, 93.9% of predictions were within 0.5 grades of expert labels, with a mean absolute error of 0.116. We further developed a deployable version that ran on Windows and Android devices, processing each image in less than 400 milliseconds. These results support scalable and more consistent ultrasound screening and follow-up in endemic regions.

Indexed as

Deep LearningLiver CirrhosisSchistosoma japonicumSchistosomiasis japonicaAnimalsHumansImage Processing, Computer-AssistedLiverUltrasonography

Identifiers

PMID42764346
PMCPMC13590604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.