Evidence map›Paper›PMID 42764340›Full record

ArticleBone research2026

Spleen-derived circulating intercellular adhesion molecule 2 promotes osteosclerosis in chronic myelofibrosis.

Sirion Aksornthong, Kerstin Tiedemann, Mélanie Welman, Alexandra Mazharian, Marie Lordkipanidzé, Yotis A Senis, Svetlana V Komarova

Abstract read
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sirion AksornthongShriners Hospital for Children, Montreal, QC, Canada.ORCID http://orcid.org/0009-0000-2174-2319
Kerstin TiedemannShriners Hospital for Children, Montreal, QC, Canada.
Mélanie WelmanResearch Center, Montreal Heart Institute, Montreal, QC, Canada.
Alexandra MazharianCentre for Cardiovascular and Nutrition Research, Institut National de la Santé et de la Recherche 1263, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement 1260, Faculty of Medicine, Aix-Marseille University, Marseille, France.
Marie LordkipanidzéResearch Center, Montreal Heart Institute, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-7418-6766
Yotis A SenisCentre for Cardiovascular and Nutrition Research, Institut National de la Santé et de la Recherche 1263, Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement 1260, Faculty of Medicine, Aix-Marseille University, Marseille, France.
Svetlana V KomarovaShriners Hospital for Children, Montreal, QC, Canada. komarova@ualberta.ca.ORCID http://orcid.org/0000-0003-3570-3147

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-165939
6 · The paper itself

Abstract

Mutations in the gene coding G6b-B, Mpig6b in mice, and MPIG6B in humans lead to myelofibrosis, progressive splenomegaly and osteosclerosis. Aberrant megakaryocyte function in bone marrow and spleen may affect bone cells through cell-cell contact or soluble factors. We aimed to assess the role of circulating factors produced by splenic cells in mediating osteosclerosis in Mpig6b

Indexed as

OsteosclerosisPrimary MyelofibrosisSpleenAnimalsChronic DiseaseFemaleFemurMiceMice, Inbred C57BLMice, KnockoutOsteoclastsSplenectomy

Identifiers

PMID42764340
PMCPMC13590502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.