Evidence map›Paper›PMID 42763925›Full record

ArticleChemistry & biodiversity2026

Chemical Characterization and Pharmacological Activity of Byrsonima crassifolia (L.) Kunth (Murici): Antinociceptive Effects, Edema Reduction, and Molecular Docking.

Lucas S Frota, Sara I C G Barbosa, Maria R C de Oiveira, Gabriela A do Nascimento, Sacha A A R Santos, Hamilton M Ishiki, Francisco E A Magalhães, Adriana R Campos, Selene M de Morais

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucas S FrotaPostgraduate Program in Biotechnology, Natural Products Chemistry Laboratory, State University of Ceará, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0001-5583-5193
Sara I C G BarbosaPostgraduate Program in Biotechnology, Natural Products Chemistry Laboratory, State University of Ceará, Fortaleza, CE, Brazil.
Maria R C de OiveiraPostgraduate Program in Nutrition and Health, State University of Ceará, Fortaleza, CE, Brazil.
Gabriela A do NascimentoNutrition Course, State University of Ceará, Fortaleza, CE, Brazil.
Sacha A A R SantosPostgraduate Program in Biotechnology, Natural Products Chemistry Laboratory, State University of Ceará, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0002-4117-2277
Hamilton M IshikiCenter For Education, Science and Technology in the Inhamuns Region, State University of Ceará, Sobral, CE, Brazil.ORCID https://orcid.org/0000-0001-5707-7656
Francisco E A MagalhãesPostgraduate Program in Nutrition and Health, State University of Ceará, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0002-4924-2882
Adriana R CamposCenter For Experimental Biology (NUBEX), University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0002-7355-9310
Selene M de MoraisPostgraduate Program in Biotechnology, Natural Products Chemistry Laboratory, State University of Ceará, Fortaleza, CE, Brazil.ORCID https://orcid.org/0000-0002-2766-3790

Funding

Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico FPD-0213-00140.01.00/23Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico PS1-00186-00240.01.00/21Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico UNI-0210-00160.01.00/23UNIFOR FEQ 50/2021
6 · The paper itself

Abstract

This study investigated the chemical composition, anti-inflammatory and antinociceptive activities of murici leaf (ELM) and bark (EBM) extracts using adult zebrafish (Danio rerio). HPLC analysis identified rutin, isoquercitrin, and kaempferol-3-O-rutinoside as the major phenolic compounds. Both extracts exhibited low toxicity and no sedative effects at the lowest tested doses. ELM showed abdominal antinociceptive activity mediated by TRPA1 and significantly reduced carrageenan-induced abdominal edema. EBM inhibited both corneal (TRPV1) and abdominal (TRPA1) nociception, producing effects similar to morphine. Molecular docking corroborated the in vivo findings, revealing favorable interactions with TRPA1, COX-2, and TRPV1, supported by stable hydrogen-bond formation. The combined chemical, biological, and computational evidence highlights murici as a promising natural source of multifunctional phytotherapeutic agents with antinociceptive activity and potential anti-inflammatory properties.

Indexed as

AnalgesicsEdemaMolecular Docking SimulationPlant ExtractsAnimalsCarrageenanDose-Response Relationship, DrugMalePlant LeavesZebrafishAnalgesicsCarrageenanPlant Extractsantinociceptive activityByrsonima crassifoliamolecular dockingphenolic compoundszebrafish

Identifiers

PMID42763925
PMCPMC13590130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.