ArticleChemistry & biodiversity2026
Design, Synthesis, and Antifungal Activity of Natural Furan Carboxylic Acid Derivatives as Potential Succinate Dehydrogenase Inhibitors.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this study, a series of furan amide derivatives were designed and synthesized from natural furan carboxylic acids as starting materials, with the aim of developing potential succinate dehydrogenase (SDH) inhibitors. The antifungal activities of the target compounds against four species of plant-pathogenic fungi were evaluated using in vitro bioassays. Structure-activity relationship (SAR) analysis revealed that the introduction of a trifluoromethyl group imparted superior antifungal activity to the compounds. Notably, compound 3m exhibited the most potent inhibitory effect against Rhizoctonia solani, with an EC
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