Evidence map›Paper›PMID 42763840›Full record

ArticleIntensive care medicine experimental2026

Automated hemodynamic resuscitation system for computer-controlled norepinephrine, vasopressin, and fluid therapy in endotoxin-induced shock: a feasibility and physiological proof-of-concept study.

Kazumasu Sasaki, Kazunori Uemura, Hiroki Matsushita, Yuta Nakamura, Kenta Ohba, Yasuyuki Kataoka, Takuya Nishikawa, Kei Sato, Hidetaka Morita, Masahiro Otake and 6 more

Abstract read
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Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Kazumasu Sasaki *Department of Anesthesiology, Akita Cerebrospinal and Cardiovascular Center, Akita, Japan. sasaki-kazumasu@akita-noken.jp.
Kazunori Uemura *NTTR-NCVC Bio Digital Twin Center, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan. kuemura@ncvc.go.jp.ORCID http://orcid.org/0000-0003-2900-4702
Hiroki MatsushitaNTTR-NCVC Bio Digital Twin Center, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Yuta NakamuraDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Kenta OhbaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Yasuyuki KataokaMedical and Health Informatics Laboratories, NTT Research, Inc., Sunnyvale, United States of America.
Takuya NishikawaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Kei SatoDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Hidetaka MoritaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Masahiro OtakeDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Nana HirakiDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Masafumi FukumitsuDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Toru KawadaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Kenji SunagawaCirculatory System Research Foundation, Tokyo, Japan.
Joe AlexanderMedical and Health Informatics Laboratories, NTT Research, Inc., Sunnyvale, United States of America.
Keita SakuNTTR-NCVC Bio Digital Twin Center, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.

Funding

Intramural research grant from the Akita Cerebrospinal and Cardiovascular Center 24-01Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering 2025K026
6 · The paper itself

Abstract

backgroundTo support hemodynamic management in vasoplegic shock, we previously developed a closed-loop automated infusion system of norepinephrine (NE) and fluid to automatically restore arterial pressure (AP) and cardiac output (CO). To enhance the practical feasibility and efficacy of the system, we integrated a minimally invasive CO monitor and a closed-loop control of vasopressin (AVP) infusion to the system and validated the integrated system in dogs with endotoxin-induced shock.

methodsBased on the circulatory equilibrium framework, the system directly controls systemic vascular resistance and stressed blood volume by titrating NE and Ringer's acetate solution (RiA), respectively, thereby restoring AP and CO. AVP is automatically initiated once infusion rate of NE is increased higher than 1 μg·kg⁻

resultsThe lipopolysaccharide infusion significantly reduced AP from 82 (80-85) to 52 (50-56) mmHg and CO

conclusionsThis proof-of-concept study validates the feasibility and physiological performance of the system for the hemodynamic management of vasoplegic shock.

Indexed as

Automated hemodynamic resuscitationCirculatory equilibrium frameworkEndotoxin shockMachine-learning analysisMinimally invasive cardiac output monitorPhysiology-driven resuscitationVasoplegic shockVasopressin

Identifiers

PMID42763840
PMCPMC13590466

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