Evidence map›Paper›PMID 42763828›Full record

ArticleHuman cell2026

Upstream regulatory mechanisms and clinical significance of IQGAP2 deficiency in affecting PI3K activity to drive cell proliferation.

Yina Zhao, Peihui Zhang, Maoting Shen, Yinxiao Xia, Kaiyuan Diao, Tao Chen, Yuhuan Meng

Abstract read
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In one paragraph

Article in Human cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yina Zhao *KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China.
Peihui Zhang *KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China.
Maoting ShenDepartment of Laboratory Medicine, Panyu Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 511400, China.
Yinxiao XiaKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China.
Kaiyuan DiaoGuangzhou KingMed Transformative Medicine Institute, Guangzhou KingMed Diagnostics Group Co. Ltd., Guangzhou, China.
Tao ChenKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China. chentao@gzhmu.edu.cn.
Yuhuan MengKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China. mengyuhuan@gzhmu.edu.cn.ORCID http://orcid.org/0000-0001-7464-3103

Funding

the National Natural Science Foundation of China 82302104the Science and Technology Program of Guangzhou 2025A03J4093
6 · The paper itself

Abstract

IQGAP2 gene defects can lead to aberrant cell proliferation and are associated with multiple diseases. Previous studies suggest that IQGAP2 knockdown can activate AKT/mTORC1 and thereby promote aberrant cell proliferation. However, the upstream molecular regulatory mechanisms remain unclear. In our study, we found that IQGAP2 knockdown enhances PI3K activity, leading to accumulation of PI(3,4,5)P

Indexed as

Cell ProliferationGene ExpressionNeoplasmsPhosphatidylinositol 3-Kinasesras GTPase-Activating ProteinsDown-RegulationHumansMechanistic Target of Rapamycin Complex 1PrognosisProto-Oncogene Proteins c-aktSignal TransductionIQGAP2 protein, humanIQ motif containing GTPase activating protein 1Mechanistic Target of Rapamycin Complex 1Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktras GTPase-Activating ProteinsCell proliferationIQGAP1IQGAP1/IQGAP2 expression ratioIQGAP2PI3K

Identifiers

PMID42763828

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.