Evidence map›Paper›PMID 42763785›Full record

ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2026

Prenatal findings and postnatal outcomes in cases of closed spinal dysraphism: 10-year two-center cohort study.

Y Athiel, E Van den Eede, T de Saint Denis, E Blondiaux, F Dhombres, P Maurice, A Dugas, H Simonnet, L Guilbaud, C Garel and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Y AthielFetal Medicine Department and National Referral Center for Rare Diseases Spin@, Hôpital Armand Trousseau, APHP Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0003-2665-8292
E Van den EedeDepartment of Obstetrics and Gynaecology, Division Woman and Child, University Hospitals Leuven, Leuven, Belgium.
T de Saint DenisPediatric Orthopedic Surgery Department, Hôpital Armand-Trousseau, APHP Sorbonne Université, Paris, France.
E BlondiauxPediatric Radiology Department, Hôpital Armand-Trousseau, APHP Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0002-2594-5428
F DhombresFetal Medicine Department and National Referral Center for Rare Diseases Spin@, Hôpital Armand Trousseau, APHP Sorbonne Université, Paris, France.
P MauriceFetal Medicine Department and National Referral Center for Rare Diseases Spin@, Hôpital Armand Trousseau, APHP Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0001-5489-3121
A DugasFetal Medicine Department and National Referral Center for Rare Diseases Spin@, Hôpital Armand Trousseau, APHP Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0002-3897-5386
H SimonnetDepartment of Physical Medicine and Rehabilitation, Hôpital Armand-Trousseau, APHP Sorbonne Université, Paris, France.
L GuilbaudFetal Medicine Department and National Referral Center for Rare Diseases Spin@, Hôpital Armand Trousseau, APHP Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0003-4695-9519
C GarelPediatric Radiology Department, Hôpital Armand-Trousseau, APHP Sorbonne Université, Paris, France.
H van der MerweDepartment of Obstetrics and Gynaecology, Division Woman and Child, University Hospitals Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-1381-4033
M AertsenDepartment of Radiology, UZ Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0003-1994-5365
P DevlooDepartment of Neurosurgery, UZ Leuven, Leuven, Belgium.
R DevliegerDepartment of Obstetrics and Gynaecology, Division Woman and Child, University Hospitals Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-7837-4684
J DeprestDepartment of Obstetrics and Gynaecology, Division Woman and Child, University Hospitals Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-4920-945X
J-M JouannicFetal Medicine Department and National Referral Center for Rare Diseases Spin@, Hôpital Armand Trousseau, APHP Sorbonne Université, Paris, France.ORCID https://orcid.org/0000-0002-7890-3790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize prenatal ultrasound findings in fetuses with prenatally diagnosed closed spinal dysraphism (CSD) and report their postnatal management and functional outcomes at 18 and 36 months.

methodsThis retrospective cohort study included all fetuses with a prenatal diagnosis of CSD assessed between January 2014 and December 2024 at two tertiary centers (Fetal Medicine Department of Trousseau Hospital, Paris, France, and Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium). Lesions were reassessed and classified according to the updated Orphanet classification system for dysraphisms. Cases of open dysraphism, intermediate forms, Currarino syndrome, caudal regression syndrome and postnatally diagnosed cases were excluded. Prenatal imaging findings, pregnancy outcomes, postnatal diagnostic concordance, neurosurgical management and functional outcomes were analyzed.

resultsSeventy fetuses with a prenatal diagnosis of CSD were included. Saccular forms of CSD accounted for 85.7% (n = 60) of cases, including 33 (47.1%) cases of limited dorsal myeloschisis, 18 (25.7%) cases of posterior meningocele and nine (12.9%) cases of conus spinal cord lipoma. Most (85.7%) lesions were located at the lumbar or sacral level. Associated structural cerebral anomalies were identified prenatally in 17.1% (n = 12) of cases. There were 59 (84.3%) live births and 11 (15.7%) terminations of pregnancy, including eight cases with major cerebral anomalies. Among liveborn infants with available data on postnatal surgical interventions (n/N = 44/59), postnatal surgery was performed in 90.9% of cases. The prenatal diagnosis was adjusted postnatally in 4/39 (10.3%) cases with available postnatal outcome data. At 36 months, independent ambulation was achieved in 94.4% (17/18) of children with follow-up data available at this time point. In contrast, urinary dysfunction was present in 38.9% of cases at 36 months, while gastrointestinal disorders were less frequent (22.2%).

conclusionUsing the Orphanet classification, prenatal ultrasound examination allows reliable anatomical characterization of CSD in 89.7% of cases. Motor outcomes are generally favorable, whereas urological morbidity is observed in nearly half of cases at 18 months. These are important elements to consider in prenatal counseling. © 2026 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Indexed as

Spinal DysraphismUltrasonography, PrenatalAdultCohort StudiesFemaleFranceHumansInfant, NewbornPregnancyPregnancy OutcomeRetrospective Studiesclosed spinal dysraphismlimited dorsal myeloschisisprenatal diagnosisultrasound

Identifiers

PMID42763785
PMCPMC13641729

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