ReviewCureus2026
GLT6D1 rs1537415 G Allele and Advanced Periodontitis: A Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis aimed to evaluate the association of the GLT6D1 rs1537415 G allele with susceptibility to periodontitis stage III/IV, grade B or C. Adhering to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, three eligible studies were identified through comprehensive searches of PubMed, Web of Science, and Scopus. Data from 2,185 participants (668 cases and 1,517 controls) were analyzed using random-effects models to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Heterogeneity was assessed using Chi² and I² statistics. Formal testing for publication bias was precluded by the small number of studies (n = 3). The meta-analysis demonstrated a significant association between the rs1537415 G allele and severe periodontitis, with a pooled OR of 1.58 (95% CI: 1.28-1.95). Subgroup analyses showed consistent associations in European and Sudanese populations, whereas no significant association was observed in the Brazilian cohort. Sensitivity analysis excluding the largest Genome-Wide Association Study (GWAS) attenuated the association to a non-significant level (OR = 1.37; 95% CI: 0.87 to 2.16), indicating that a single study largely drove the overall effect; the pooled estimate should therefore be interpreted with caution. The GLT6D1 rs1537415 G allele may represent a genetic risk factor for severe periodontal diseases, particularly stage III/IV and grade B/C, suggesting a possible role in immune modulation. Further research involving larger, multi-ethnic cohorts is crucial to validate these associations and explore gene-environment interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.