ReviewClinical ophthalmology (Auckland, N.Z.)2026
Evidence-Based Clinical Practice Guideline for Diagnosis, Treatment, and Follow-Up of Keratoconus Patients.
Review in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratoconus is a progressive corneal ectatic disorder characterized by focal stromal thinning and conical protrusion, typically involving the central or paracentral cornea. Disease progression may lead to significant visual impairment and reduced quality of life. Reported global prevalence ranges from 0.17 to 40 cases per 1000 persons, reflecting differences in diagnostic criteria, imaging technologies, and study populations. Early detection, timely intervention, and risk-based follow-up are essential to limit progression and reduce visual morbidity. A systematic literature search did not identify existing clinical practice guidelines for keratoconus diagnosis and management with sufficient methodological quality to support adoption or adaptation. Therefore, a de novo evidence-based clinical practice guideline was developed. The objective was to provide recommendations for timely diagnosis, risk stratification, interventional treatment, and follow-up of pediatric and adult patients with keratoconus, aiming to standardize clinical criteria and support decision-making among healthcare professionals. The guideline was developed through systematic evidence synthesis and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess certainty of evidence and strength of recommendations. The evidence base included systematic reviews, diagnostic accuracy studies, randomized clinical trials, and observational studies, according to each clinical question. Recommendations addressed risk factors, diagnostic and staging criteria, progression assessment, corneal cross-linking protocols, intrastromal corneal ring segments, keratoplasty techniques, and individualized follow-up. Most recommendations were conditional, reflecting low or very low certainty of evidence in several domains. This guideline provides a practical framework for standardized keratoconus care while explicitly identifying areas where evidence remains limited and further research is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.