ArticleCureus2026
Emerging Resistance and Shifting Bacterial Profiles in Lower Respiratory Tract Infections: A Tertiary Care Perspective.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
Background and objective Lower respiratory tract infections (LRTIs) continue to pose a significant global public health concern, with bacterial agents responsible for a considerable proportion of cases requiring hospitalization and antibiotic treatment. The increasing emergence of antimicrobial resistance (AMR) among respiratory pathogens further complicates disease management and clinical outcomes. This study aimed to identify the bacterial profile of clinical LRTI cases and to determine the antimicrobial susceptibility of the identified pathogens. Materials and methods The study involved laboratory-based investigation of bacterial isolates from hospitalized patients with clinical suspicion of LRTI at Krishna Hospital and Medical Research Center, Karad, India, over one year from May 2024 to May 2025. Clinical specimens, such as endotracheal aspirates, sputum, and pleural fluid samples, were processed according to standard microbiological protocols. Results The study included 120 cases of confirmed LRTI. The 20-29 years age category exhibited the greatest infection burden, representing 35 (29.17%) cases, while the 30-39 years age group followed with 26 (21.67%) cases. Males were more frequently impacted than females, accounting for 77 (64.17%) cases versus 43 (35.83%). Of the 120 bacterial isolates obtained,
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