Evidence map›Paper›PMID 42763592›Full record

ArticleFASEB bioAdvances2026

The Human PNPLA3

Gertrude Arthur, Michael I Adenawoola, Sally Wahba, Bentley S Montgomery, Claire B Wingfield, Zachary A Kipp, Terry D Hinds, David E Stec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB bioAdvances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gertrude ArthurDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Michael I AdenawoolaDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Sally WahbaDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Bentley S MontgomeryDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Claire B WingfieldDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center University of Mississippi Medical Center Jackson Mississippi USA.
Zachary A KippDepartment of Pharmacology and Nutritional Sciences University of Kentucky Lexington Kentucky USA.
Terry D HindsDepartment of Pharmacology and Nutritional Sciences University of Kentucky Lexington Kentucky USA.
David E StecDepartment of Physiology & Biophysics, Cardiorenal, and Metabolic Diseases Research Center University of Mississippi Medical Center Jackson Mississippi USA.ORCID https://orcid.org/0000-0001-8359-4008

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The patatin-like phospholipase domain-containing protein 3 (Pnpla3) I148M polymorphism is a well-established genetic determinant of metabolic dysfunction-associated steatotic liver disease (MASLD), and emerging evidence links it to chronic kidney disease (CKD) and cardiovascular disease (CVD). However, the mechanisms underlying this relationship remain unclear. The goal of this study was to investigate the role of the Pnpla3

Indexed as

hyperfiltrationhypertensionkidneykinomelivertransporters

Identifiers

PMID42763592
PMCPMC13589268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.