Evidence map›Paper›PMID 42763401›Full record

ArticleEye and vision (London, England)2026

Establishing a precision reference benchmark for corneal epithelial aberration measurements using a new hybrid device across keratoconus stages.

Yizhou Yang, Rui Ning, Siheng Li, Xinning Yang, Yiran Wang, Kexin Li, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinhai Huang

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Article in Eye and vision (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yizhou Yang *Eye Institute and Department of Ophthalmology, NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Eye & ENT Hospital, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China.
Rui Ning *Refractive Center, The Affiliated Hospital of Yunnan University, Kunming, China.
Siheng Li *Eye Institute and Department of Ophthalmology, NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Eye & ENT Hospital, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China.
Xinning YangEye Institute and Department of Ophthalmology, NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Eye & ENT Hospital, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China.
Yiran WangNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Kexin LiEye Institute and Department of Ophthalmology, NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Eye & ENT Hospital, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China.
Giacomo SaviniIRCCS Bietti Foundation, Rome, Italy.
Domenico Schiano-LomorielloIRCCS Bietti Foundation, Rome, Italy.
Xingtao ZhouEye Institute and Department of Ophthalmology, NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Eye & ENT Hospital, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China.
Jinhai HuangEye Institute and Department of Ophthalmology, NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Eye & ENT Hospital, Fudan University, Chinese Academy of Medical Sciences, Shanghai, China. vip999vip@163.com.

Funding

Fund of Fudan University and Cao'ejiang Basic Research 24FCA16National Health Commission National Key Clinical Specialty Construction Project Z155080000004the Clinical Research Program of the Shanghai Municipal Health Commission 202540083the Eye & ENT Hospital of Fudan University High-level Talents Program 2021318Yunnan University Medical Research Foundation YDYX12025-0057
6 · The paper itself

Abstract

backgroundTo establish a precision reference benchmark for corneal epithelial aberration measurements across different stages of keratoconus (KC) by evaluating the precision of a new spectral-domain optical coherence tomography-Placido disk device (MS-39; CSO).

methodsEyes with KC were classified into forme fruste keratoconus (FFKC), mild, moderate, and severe disease stage. Three consecutive corneal epithelial aberration measurements were obtained with the MS-39 by two skilled operators. The intraobserver repeatability and interobserver reproducibility were evaluated using within-subject standard deviation (S

resultsThe prospective study enrolled 141 eyes from 141 KC subjects. Subgroups included 32 eyes with FFKC, 29 with mild, 45 with moderate, and 35 with severe KC. In the FFKC, mild, moderate, and total groups, S

conclusionsThe new MS-39 device demonstrated moderate-to-good precision in corneal epithelial aberration measurements for FFKC, mild, moderate and total KC. Despite the decrease associated with increasing KC severity, the potential of the device for early diagnosis and monitoring was still evident. The instrument's precision should be tailored to disease severity. Stage-specific TRT thresholds for epithelial aberration measurements were proposed for KC management.

Indexed as

Corneal epithelial aberrationKeratoconusPrecisionThresholds

Identifiers

PMID42763401
PMCPMC13589856

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