Evidence map›Paper›PMID 42763377›Full record

ArticleBiotechnology letters2026

Coupling continuous directed evolution with base editors identifies combinatorial antibiotic resistance.

Hong Wang, Jiamei Wang, Di Zhang, Guangdong Shang

Abstract read
PubMed Publisher
In one paragraph

Article in Biotechnology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hong WangJiangsu Key Laboratory for Pathogens and Ecosystems, College of Life Sciences, Jiangsu Province, Nanjing Normal University, No.1 Wenyuan Rd, Xixia District, Nanjing, 210023, P. R. China.
Jiamei WangJiangsu Key Laboratory for Pathogens and Ecosystems, College of Life Sciences, Jiangsu Province, Nanjing Normal University, No.1 Wenyuan Rd, Xixia District, Nanjing, 210023, P. R. China.
Di ZhangJiangsu Key Laboratory for Pathogens and Ecosystems, College of Life Sciences, Jiangsu Province, Nanjing Normal University, No.1 Wenyuan Rd, Xixia District, Nanjing, 210023, P. R. China.
Guangdong ShangJiangsu Key Laboratory for Pathogens and Ecosystems, College of Life Sciences, Jiangsu Province, Nanjing Normal University, No.1 Wenyuan Rd, Xixia District, Nanjing, 210023, P. R. China. shanggd@hotmail.com.ORCID http://orcid.org/0000-0001-6142-3785

Funding

National Natural Science Foundation of China NSFC 82073742
6 · The paper itself

Abstract

Antimicrobial resistance (AMR), mainly caused by the mutation of antibiotic resistance genes, poses a great threat to human health. Clinically, TEM-1 β-lactamase encoding bla

Indexed as

beta-LactamasesDirected Molecular EvolutionDrug Resistance, BacterialEscherichia coliGene EditingAnti-Bacterial AgentsCefotaximeChromosomes, Artificial, BacterialMicrobial Sensitivity TestsMutationAnti-Bacterial Agentsbeta-Lactamasesbeta-lactamase TEM-1CefotaximeBase editorContinuous directed evolutionMinimum inhibitory concentrationRecombineeringTEM-1

Identifiers

PMID42763377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.