ArticleInternational journal of obesity (2005)2026
Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe association between nocturnal intermittent hypoxia and metabolic syndrome (MetS) in individuals without abdominal obesity has not yet been fully explored. We conducted a longitudinal study to investigate the association between nocturnal intermittent hypoxia and the incidence of MetS and its components in Japanese individuals without abdominal obesity.
methodsThis prospective cohort study included 647 participants without baseline MetS and abdominal obesity, defined as a waist circumference of <90 cm in men and <80 cm in women. Nocturnal intermittent hypoxia was assessed using 3% oxygen desaturation index (ODI). MetS was diagnosed according to the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Incident MetS and its components were assessed at the five-year follow-up survey. The median follow-up period was 5.0 years (IQR, 4.8-5.1). The association between nocturnal intermittent hypoxia and the incidence of MetS and its components was evaluated using a modified Poisson regression analysis. The analysis was stratified by age group (<65 years vs. ≥65 years).
resultsIn the younger age group, 3% ODI ≥ 5 was associated with a significantly higher risk ratio (RR) for MetS incidence (RR 2.10, 95% confidence interval [CI]: 1.18-3.76). Participants with 3% ODI ≥ 5 in the younger age group also had significantly higher RRs for abdominal obesity (RR 2.17, 95% CI: 1.42-3.33), low high-density lipoprotein cholesterol (RR 2.01, 95% CI: 1.02-3.96), and hypertriglyceridemia (RR 2.41, 95% CI: 1.35-4.30). In the older age group, 3% ODI ≥ 5 was not significantly associated with increased RRs for MetS or its components.
conclusionsNocturnal intermittent hypoxia was associated with an increased risk of developing MetS and some of its components in younger individuals without abdominal obesity.
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