Trial reportZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Effects of a lung recruitment maneuver combined with individualized positive end-expiratory pressure on postoperative pulmonary complications and perioperative hemodynamics in hypertensive patients undergoing pulmonary resection].
Trial report in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesA lung recruitment maneuver (LRM) combined with a dynamic lung compliance-guided positive end-expiratory pressure (PEEP) strategy can reduce the risk of postoperative pulmonary complications (PPCs) in patients undergoing pulmonary resection. However, the lung-protective effects of this strategy and its impact on hemodynamics in patients with hypertension remain unclear. This study aims to evaluate the effects of an LRM combined with a dynamic lung compliance-guided PEEP strategy on PPCs and perioperative hemodynamics in hypertensive patients undergoing thoracoscopic pulmonary resection, thereby providing scientific evidence for the safe application of this strategy in this population.
methodsA total of 100 hypertensive patients scheduled to undergo thoracoscopic pulmonary resection with one-lung ventilation (OLV) at the Affiliated Hospital of Jiangnan University between November 28, 2024 and August 15, 2025 were enrolled. Using a random number table, the patients were assigned to a conventional protective ventilation group (control group) or an LRM combined with individualized PEEP group (intervention group), with 50 patients in each group. In the control group, intraoperative PEEP was set at 5 cmH
resultsThere were no statistically significant differences in preoperative baseline characteristics between the control and intervention groups (all
conclusionsAn LRM combined with individualized PEEP can reduce the incidence of PPCs. Although this strategy is associated with a higher incidence of intraoperative hypotension, most episodes can be rapidly corrected with timely intervention, are of short duration, and do not adversely affect postoperative cardiac or renal function. Older patients, those with grade 3 hypertension, and overweight patients may be at greater risk of intraoperative hypotension; therefore, enhanced intraoperative hemodynamic monitoring and timely individualized management are warranted.
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