ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
Association between dietary folic acid intake and diabetic retinopathy among patients with diabetes: An analysis of 2005-2008 NHANES data.
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesDietary folic acid (FA) intake may reduce homocysteine levels and alleviate oxidative stress, both of which are closely associated with the development and progression of diabetic retinopathy (DR). This study aims to investigate the association between dietary FA intake and DR among patients with diabetes aged ≥40 years in the United States.
methodsData from the 2005-2008 National Health and Nutrition Examination Survey (NHANES) were used. The study population comprised 3 220 patients previously diagnosed with type 2 diabetes mellitus, after excluding patients with diabetes who had missing data on dietary FA intake or DR. Multivariable logistic regression was used to evaluate the association between dietary FA intake and the prevalence of DR, with subgroup analyses and interaction tests performed. Smooth curve fitting was used to explore the potential nonlinear relationship between dietary FA intake and DR.
resultsAfter adjustment for potential confounders, higher dietary FA intake was significantly associated with a lower prevalence of DR (
conclusionsAmong adults with diabetes aged ≥40 years in the United States who were diagnosed clinically or based on biochemical testing, higher dietary FA intake is significantly associated with a lower prevalence of DR. Future prospective studies are needed to clarify the causal relationship and underlying mechanisms.
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