ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
Association of wearable
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesIt remains unclear whether the degree of fragmentation modifies the adverse health outcomes associated with prolonged sedentary behavior. This study aims to investigate the associations of objectively measured sedentary patterns with incident cardiovascular disease (CVD), mortality, and life expectancy.
methodsThis prospective cohort study included 89 010 UK Biobank participants (median age 63.5 years, 56.5% women) who provided 3 to 7 valid days of wrist accelerometer data. Daily sedentary time and number of sedentary breaks were the metrics of interest. Four overall sedentary behavior patterns were identified by joint classification of sedentary time and number of sedentary breaks. Outcomes were all-cause mortality, CVD incidence and mortality, CVD-free life expectancy, and total life expectancy. Multivariable Cox proportional hazards models were used to evaluate the associations of sedentary behavior metrics with all-cause mortality and CVD incidence, whereas Fine-Gray competing-risk models were used to evaluate their associations with cardiovascular mortality, with non-CVD death treated as a competing event. Restricted cubic splines were used to assess potential nonlinear associations. Multi-state survival analyses were performed to estimate CVD-free life expectancy. Isotemporal substitution models were used to estimate the effects of replacing sedentary time with moderate-to-vigorous physical activity (MVPA).
resultsDuring a median follow-up of 8.0 years, 3 730 deaths occurred, including 1 223 CVD deaths and 8 883 incident CVD cases. Total sedentary time showed J-shaped dose-response associations with all-cause and cardiovascular mortality and a linear association with increased CVD incidence. The number of sedentary breaks showed L-shaped associations with risks of all-cause mortality and CVD mortality. Compared to the least sedentary group, participants with prolonged sedentary time (≥10 h/d) and a low degree of fragmentation (sedentary break <12 bouts/d) had a 51.5% higher risk of all-cause mortality [hazard ratio (
conclusionsProlonged sedentary time and its uninterrupted accumulation patterns are associated with greater risks of mortality and CVD, alongside reductions in CVD-free life expectancy. The increased mortality risk and the loss of CVD-free years may be mitigated by frequent interruptions to sedentary behavior.
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