ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Role of AHR-mediated histone acetylation at FOXP3 in Tfr cell differentiation in systemic lupus erythematosus].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by abnormal autoantibody production, immune dysregulation, and multisystem involvement. This study aims to investigate the effects of aryl hydrocarbon receptor (AHR) activation on the differentiation of T follicular regulatory (Tfr) cells and the expression of forkhead box protein P3 (FOXP3) in patients with SLE, and to elucidate the underlying molecular mechanisms from an epigenetic perspective.
methodsEighteen patients with SLE who attended the Departments of Dermatology and Rheumatology and Immunology of The Third Xiangya Hospital, Central South University, between June and December 2025, and 18 healthy individuals undergoing routine health examinations were enrolled. In addition, 3 healthy volunteers were recruited for peripheral blood collection for mechanistic experiments. Peripheral blood mononuclear cells (PBMCs) were isolated by density-gradient centrifugation, and CD4
resultsCompared with healthy controls, patients with SLE had a significantly lower Tfr% among peripheral blood CD4
conclusionsThe reduced Tfr% and decreased FOXP3 expression in peripheral blood CD4
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