ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[NPLOC4 promotes proliferation, invasion, and migration of hepatocellular carcinoma cells via enhancing Wnt/
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesDysregulation of mitophagy contributes to the initiation and progression of hepatocellular carcinoma (HCC). Nuclear protein localization 4 homolog (NPLOC4) is an essential protein involved in various cellular processes and has been implicated in multiple cancers. Recent studies have suggested that NPLOC4 participates in the regulation of mitophagy; however, its role in HCC remains unclear. This study aims to investigate the role of NPLOC4 in mitophagy and its underlying regulatory mechanisms in HCC.
methodsRNA sequencing data from the GSE277232 and GSE251942 datasets obtained from the Gene Expression Omnibus (GEO) database were analyzed together with mitophagy-related genes collected from the GeneCards database to identify differentially expressed mitophagy-related genes in HCC. NPLOC4 expression was further analyzed and validated by Western blotting. Small interfering RNA (siRNA)-mediated knockdown of
resultsBioinformatics analysis identified
conclusionsNPLOC4 is highly expressed in HCC. Downregulation of NPLOC4 inhibits activation of the Wnt/β-catenin signaling pathway, thereby inhibiting mitophagy and ultimately inhibiting HCC cell proliferation, migration, and invasion. These findings suggest that NPLOC4 may serve as a potential biomarker and therapeutic target for HCC.
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