Evidence map›Paper›PMID 42762572›Full record

ArticleClinics (Sao Paulo, Brazil)2026

Steatosis worsens ischemia-reperfusion injury post hepatectomy with intermittent inflow occlusion.

Hui Chen, Biao Duan, Shiyu Yang, Nuo Pan, Kun Tao, Xiaohui Liu, Bing Hu, Jun Chen, Weifeng Tan

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In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hui ChenDepartment of Endoscopy, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China; Department of Hepatobiliary and Pancreatic Surgery, Tongji Hospital Affiliated to Tongji University, Shanghai, 200333, China.
Biao DuanDepartment of Hepatobiliary and Pancreatic Surgery, Tongji Hospital Affiliated to Tongji University, Shanghai, 200333, China.
Shiyu YangBaoshan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nuo PanKangda College, Nanjing Medical University, Jiangsu province, Lianyungang, China.
Kun TaoDepartment of Pathology, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Xiaohui LiuDepartment of Pathology, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Bing HuDepartment of Endoscopy, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address: drhubing@aliyun.com.
Jun ChenBaoshan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: chenjuntcdj@126.com.
Weifeng TanDepartment of Hepatobiliary and Pancreatic Surgery, Tongji Hospital Affiliated to Tongji University, Shanghai, 200333, China. Electronic address: twf1231@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntermittent Vascular Inflow Occlusion (VIO) is widely used during hepatectomy, but its impact on Liver Ischemia-Reperfusion Injury (LIRI) - especially in steatotic livers - remains debated. This study aims to evaluate the effects of VIO and hepatic steatosis on LIRI severity and postoperative recovery after hepatectomy.

methodsA retrospective cohort study analyzed 200 patients undergoing hepatectomy. Patients were divided into three groups according to the number of hepatic inflow occlusion episodes: N-VIO (no occlusion, n = 136), F-VIO (few-VIO, 1-2 occlusions, n = 35), and M-VIO (multiple-VIO, ≥ 3 occlusions, n = 29). After 1:1:1 Propensity Score Matching (PSM) based on surgical approach and tumor characteristics, 23 matched triplets were generated among the three groups. Liver function (ALT, AST) was assessed preoperatively and on Postoperative Days-3 (POD3) and 7 (POD7). Steatosis effects were evaluated.

resultsAt POD3, the three groups exhibited a trending overall difference in ALT levels before PSM (p = 0.009). Following PSM, no significant intergroup differences were observed at either POD3 (p = 0.422) or POD7 (p = 0.156). Collectively, these results suggest that, within the confines of the present study, variations in the number of hepatic inflow occlusions do not translate into significant differences in early postoperative ALT recovery. Steatosis significantly exacerbated IRI, with higher ALT in steatosis patients at POD3 (p = 0.026) and POD7 (p = 0.006).

conclusionsAppropriate VIO does not exacerbate LIRI. Steatosis heightens LIRI susceptibility. Patients with liver steatosis should pay more attention to controlling the number of VIO during the operation.

Indexed as

HepatectomyHepatoprotectiveLiver ischemia-reperfusion injurySteatosisVascular inflow occlusion

Identifiers

PMID42762572
PMCPMC13627793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.